The Hematology Gene and Cell Therapy Program has an excellent opportunity for a talented researcher to join our highly collaborative team of research scientists and clinical researchers working on gene therapy, gene editing for hematopoietic disorders, and animal models of human diseases.
About the role: The Malik lab at Cincinnati Children's Hospital Medical Center has led many gene therapy studies on hematopoietic stem cell disorders, such as hemoglobinopathies (thalassemia and sickle cell disease), immune deficiency (X-SCID) and immune dysregulatory disorders (HLH) and using a variety of viral vectors and have translated these efforts with retroviral and lentiviral vectors into clinical trials for these diseases. The lab is now focused on gene editing for hematopoietic diseases, with a focus on designing platforms that primarily mediate homology directed repair. We have an exciting opportunity for a talented Research Associate to contribute and lead a gene editing project. Experiments could be designed to take advantage of existing expertise in human hematopoietic stem cell xenograft models and mouse models of these genetic disorders, the ability of the lab to use these models and technologies for discovery and translation of lentiviral gene therapy trials, single-cell sequencing, CRISPR/Cas gene editing and patient-derived hematopoietic stem cells. The successful applicant will lead a gene editing project and work with a team of experimental biologists within the Malik Lab to generate high quality in vitro and in vivo data that can result in high impact publications, as well as foster grant applications and career development to a faculty level position in 2-3 years.
Required: ??? PhD ??? 3 - 5 years of work experience in a related job discipline
About you: You will have a PhD and postdoctoral experience in hematology or hematopoiesis, molecular biology, molecular biology, genetics, immunology, or a related discipline, evidenced by a strong publication record, including first author papers. You will have a vision and passion for hematopoietic disease and discovery research that will be a major advancement in the field, or potentially translate to improve patient outcomes. You enjoy staying abreast of new genomic and cellular technologies, methodologies, and institute strategy to help identify future research opportunities and contributing to grant writing. You adopt an open and collaborative approach to scientific research, value a positive team culture, and are looking to build on your developing management and leadership skills.
Essential Skills: ??? Demonstrated experience in the design, analysis, and interpretation of experiments. ??? A growing scientific independence with an ability to solve problems and a desire to make a personal contribution to scientific research. ??? Line-management or supervisory experience, with a strong desire to further develop leadership skills. ??? An attention to detail and ability to work to tight timelines. ??? An ability to communicate effectively with scientists from multiple disciplines, including computational and clinical.
At Cincinnati Children’s, we come to work with one goal: to make children’s health better. We believe in a team approach, both in caring for patients and their families, and in advancing science and discovery. We strive to do better, and find energy and inspiration in our shared purpose. If you want to be the best you can be, you can do it at Cincinnati Children’s.